I just got a new laptop and seems that technology is going away from the old Serial Ports and replacing them with USB. I purchased a USB to Serial Port adapter cable (about $40 at Radio Shack - You can get them cheaper online but figured I could take it back easier if it didn't work). Luckily it worked with HPTuner. 2 of my other programming/editing programs wouldn't work with it though. One was a DOS program (DOS doesn't support USB) and not sure why the other one doesn't work. HPTuner didn't seem to communicate quite as well but it did work OK. I ended up trading it for a different model with Serial Port though.
Later, Rick @ STS
www.ststurbo.com