My searching has left me with more questions than answers. I've posted this question on a Facebook group (Goat Rope) and received some helpful guiding from a couple of guys, but I'm just taking wild swings with the knowledge they've shared and I can't make any good progress.
e67, 4.8, 218/227 112+2 cam, otherwise stock. Paid for a tune from a reputable Mail Order place, and the customer service and the tune itself was enough to make me start learning this myself. VVE/MAF are really close in the closed loop areas, but the truck won't cold start worth a damn. It will crank over and light off quick enough, but the transition to Open Loop after that is rough, and the truck dies very quickly. I can restart it, but it doesn't stay running without throttle input until there's a little heat in the motor (I'm guessing?).
smokeshow suggested I look at the Open Loop IVT table, and I increased it by about 10% in the lower rows and that helped it hit targeted fuel numbers, but it still doesn't stay running at all. Other threads have indicated drastically increasing these values (increasing the values by 60% total) are what's needed, so I tried that and it wouldn't even start. I dropped back to the increased IVT values, and can at least pedal it to keep it going.
The truck runs and drives well enough, and to be honest I'm sure I could eventually stumble upon the correct combination of values to get it going... But I'm hoping someone can fast-track me by pointing out my failings with my current calibration.