Originally Posted by
Higgs Boson
i can't see the tune on this computer but low rpm high load/map is called lugging the motor and it will knock easily if you have too much spark in it, this is why factory tables are negative there. so, if you have too much spark lead in those cells it is probably crying out in pain.
if you have a cam then it is also most likely advanced on the intake vs a stock cam creating even more cylinder pressure and needing even less spark lead.
are you logging knock? put the car in open loop and check your fueling with a wideband to make sure it's spot on instead of using trims, especially if you have long tubes, the sensor delay might also be wrong and they are inaccurate at low flow.